Matrix metalloproteinases

Abstract

Background The matrix metalloproteinases (MMPs) have a role in gastrointestinal malignancy. This role is reviewed, with particular reference to the gelatinase subgroup of enzymes. Methods All relevant papers derived from the Medline and Enbase databases between 1984 and early 1996 were reviewed. Result and Conclusion There is now strong evidence that MMPs play a major role in tumour invasion and metastasis. The development of MMP inhibitors may lead to important new treatment for the control of malignant disease.