Facile Hydrothermal Synthesis of Cubic Zinc Ferrite Nanoparticles for Electrochemical Detection of Anti-inflammatory Drug Nimesulide in Biological and Pharmaceutical Sample

Abstract

In this present work, a cubic ZnFe2O4 NPs was prepared using facile hydrothermal method. The as-prepared ZnFe2O4 NPs capably employed for the detection of anti-inflammatory drug Nimesulide (NS) with the surface modification on the glassy carbon electrode (GCE). The physicochemical properties of as-prepared ZnFe2O4 NPs were characterized by XRD, FTIR, FESEM, HR-TEM, and XPS analysis. The electrocatalytic efficiency was investigated through EIS, CV, and DPV electroanalytical techniques. The obtained electroanalysis result demonstrated excellent electrocatalytic activity towards the detection of NS. The constructed ZnFe2O4 NPs modified electrode achieved a good linear ranging from 0.001 to 166 μM with a detection limit of 0.006 μM. The calculated analytical sensitivity of the sensor was 0.625 μA μM-1 cm-2. Moreover, the modified electrode delivers good storage stability, reproducibility and repeatability. Evidently, the proposed sensor manifests the determination of NS in human urine samples and nimesulide tablets for practical applications.