Palladium-Catalyzed Ring-Closing Reaction for the Synthesis of Saturated <i>N</i>-Heterocycles with Aminodienes and <i>N,O</i>-Acetals

Abstract

An efficient palladium-catalyzed ring-closing reaction of aminodienes with <i>N,O</i>-acetals for the synthesis of saturated <i>N</i>-heterocycles is described. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups with volatile MeOH as the sole byproduct. This method provides rapid and practical access to a broad range of saturated <i>N</i>-heterocycles with diverse structural backbones that are useful building blocks in natural product synthesis and drug discovery.