Pfizer-BioNTech mRNA BNT162b2 Covid-19 vaccine protection against variants of concern after one versus two doses

Abstract

Key messages and recommendations\nThispopulation-based study documentsBNT162b2vaccine protection week-by-week after the first dose.\n75% of protection against infection and disease is reached 15-21 daysafter the first dose.\nProtection increased most rapidly against hospitalization and death and slowest against B.1.351infection.While protection of one dose beyond 21 days could not be assessed, findings support delaying the second vaccinedosein situations of limited vaccine suppliesand high incidences.