RSC Advances · 2021 · 37 citations · 25 references
PharmacyPharmaceutical AnalysisPharmaceuticsAnalytical ChemistryChromatographic AnalysisMass Spectrometric AnalysisChromatographic Analysis Of PharmaceuticalsChromatographyCounterfeit Drug DetectionDrug IdentificationInstrumental AnalysisSpectroscopic Analysis Of PharmaceuticalsChromatographic ScreeningCounterfeit Antibiotic DetectionCounterfeit PharmaceuticalsDensitometric AnalysisQuantification Of AnalytesRf Value AnalysisRf Value DeterminationSpectroscopic Drug Authentication
value of ofloxacin and ornidazole was calculated to be 0.12 and 0.76, respectively. The densitometric method yielded a linearity of ofloxacin and ornidazole in the range of 5-40 μg/band and 5-50 μg/band, respectively. The limit of detection was found to be 0.8 μg/spot for ofloxacin and 1.1 μg/spot for ornidazole. The proposed method has been successfully applied for the determination of ofloxacin and ornidazole present in more than one pharmaceutical dosage form and was comparable to the densitometric method.
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