Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network

Abstract

We report EGCG, a green tea polyphenol, as a modulator of <i>in vitro</i> methylglyoxal-induced Tau glycation and its impact on reducing advanced glycation end products in neuroblastoma cells. We unravel unprecedented function of EGCG in remodeling neuronal cytoskeletal integrity.