Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight

Abstract

Anthraquinones (ANQs) isolated from <i>Paederia</i> plants are known to have antidiarrheal, antitussive, anthelmintic, analgesic, anti-inflammatory, antihyperlipidemic, antihyperglycaemic, and antimicrobial activities. The antioxidant properties were also noted but not confirmed thus far. In this study, the superoxide and hydroperoxide radical scavenging activities of six ANQs were evaluated using a computational approach. The results suggest that the ANQs exhibit low HOO^• antiradical activity in all environments, including the gas phase (<i>k</i> < 10² M^-1 s^-1). In contrast, the ANQs might exert excellent O₂ ^•- radical scavenging activity, particularly in aqueous solution. The rate constants of the superoxide anion scavenging in water (at pH = 7.4) range from 3.42 × 10⁶ to 3.70 × 10⁸ M^-1 s^-1. Compared with typical antioxidants such as ascorbic acid and quercetin, the superoxide anion scavenging activity of ANQs is significantly higher. Thus, the ANQs are promising O₂ ^•- radical scavengers in polar media.