Rapid Access to <i>N</i>-Protected Sulfonimidoyl Fluorides: Divergent Synthesis of Sulfonamides and Sulfonimidamides

Abstract

Herein we report a practical and efficient copper-catalyzed approach for the conversion of various arenediazonium salts to the corresponding <i>N</i>-protected sulfonimidoyl fluorides. This operationally simple protocol tolerates a wide range of functional groups and can be applied to the late-stage modification of complex bioactive molecules. Furthermore, pharmaceutically important primary sulfonamides and sulfonimidamides derived from these valuable <i>N</i>-protected sulfonimidoyl fluoride units were prepared in minimal synthetic steps.