The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer’s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats

Abstract

These data demonstrate that chronic exposure to ambient TRAP promoted AD phenotypes in wildtype and genetically susceptible rats. TRAP effects varied according to age, sex, and genotype, suggesting that AD progression depends on complex interactions between environment and genetics. These findings suggest current <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mrow><mml:mrow><mml:mi>PM</mml:mi></mml:mrow></mml:mrow><mml:mrow><mml:mrow><mml:mn>2.5</mml:mn></mml:mrow></mml:mrow></mml:msub></mml:mrow></mml:math> regulations are insufficient to protect the aging brain. https://doi.org/10.1289/EHP8905.