DMSA-Coated Cubic Iron Oxide Nanoparticles as Potential Therapeutic Agents

Abstract

<b>Aim:</b> Superparamagnetic cubic iron oxide nanoparticles (IONPs) were synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as a potential agent for cancer treatment. <b>Methods:</b> Monodisperse cubic IONPs with a high value of saturation magnetization were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, and their cytotoxic effects on HeLa cells were investigated. <b>Results:</b> DMSA functionalized cubic IONPs with an edge length of 24.5 ± 1.9 nm had a specific absorption rate value of 197.4 W/g_Fe (15.95 kA/m and 488 kHz) and showed slight cytotoxicity on HeLa cells when incubated with 3.3 × 10¹⁰, 6.6 × 10¹⁰ and 9.9 × 10¹⁰ NP/mL for 24, 48 and 72 h. <b>Conclusion:</b> To the best of our knowledge, this is the first study to investigate both the cytotoxic effects of DMSA-coated cubic IONPs on HeLa cells and hyperthermia performance of these nanoparticles.