Comparative 1-Year Outcomes of Invasive <i>Staphylococcus aureus</i> Infections Among Persons With and Without Drug Use: An Observational Cohort Study

Abstract

Compared to non-PWUD, PWUD with invasive S. aureus infections had lower rates of antibiotic completion and twice the risk of infection persistence/recurrence at 1 year. Among PWUD, both opioid and stimulant use were common. Models for combined treatment of substance use disorders and infections, particularly MRSA, are needed.