Vadadustat in Patients with Anemia and Non–Dialysis-Dependent CKD

Abstract

Vadadustat, as compared with darbepoetin alfa, met the prespecified noninferiority criterion for hematologic efficacy but not the prespecified noninferiority criterion for cardiovascular safety in patients with NDD-CKD. (Funded by Akebia Therapeutics and Otsuka Pharmaceutical; PRO₂TECT ClinicalTrials.gov numbers, NCT02648347 and NCT02680574.).