Cross-Coupling of Ketone Enolates with Grignard and Zinc Reagents with First-Row Transition Metal Catalysts

Abstract

The stereoselective transformation of ketones to substituted olefins has become of great importance in organic synthesis. This Review helps to define the scope and limitations of the first-row transition metal-catalyzed cross-couplings between various enolates and aryl, heteroaryl, alkenyl, alkynyl, and alkyl Grignard and zinc reagents.