Increased Dysfunctional and Plastic Regulatory T Cells in Idiopathic Orbital Inflammation

Abstract

Increased Tregs with proinflammatory and profibrotic polarization were first identified in IOI, suggesting that Treg plasticity and heterogeneity plays an essential role in IOI pathogenesis. Additionally, our study identified a regulatory effect of IL-33 on inflammation and fibrosis in IOI. Reversing the plastic Tregs <i>via</i> IL-33 might be a potential option for IOI patients.