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Distinct Response to Platinum-Based Chemotherapy among Patients with Metastatic Castration-Resistant Prostate Cancer Harboring Alterations in Genes Involved in Homologous Recombination

DOI

17

Citations

0

References

2021

Year

Liancheng Fan, Xiaochen Fei, Yinjie Zhu, Chenfei Chi, Jiahua Pan, Jianjun Sha, Zhixiang Xin, Yiming Gong, Xinxing Du, Yanqing Wang,
The Journal of Urology

Abstract

The patients with mCRPC harboring alterations in different HR genes displayed distinct response to platinum-based chemotherapy. Patients with mCRPC harboring genomic defects in crucial HR genes either in the germline or somatic, especially <i>BRCA2</i> and <i>ATM</i>, might experience superior outcomes to platinum-based chemotherapy, compared with those harboring <i>CDK12</i> defect.