Concepedia

VEGFR2 inhibition hampers breast cancer cell proliferation <i>via</i> enhanced mitochondrial biogenesis

Hao Ni, Min Guo, Xuepei Zhang, Lei Jiang, Shuai Tan, Juan Yuan, Huanhuan Cui, Yanan Min, Junhao Zhang, Susanne Schlisio,

Cancer Biology and Medicine · 2021 · 31 citations · 23 references

DOIFull text

Open access

Abstract

VEGF enhances cancer cell proliferation by decreasing Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis, ROS production, and cell apoptosis. These findings suggested the anticancer potential of Ki8751 <i>via</i> increased mitochondrial biogenesis and ROS production.

References

23

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Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2016 · 16.1K citations · Full text

Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer

Reiki Nishimura, Tomofumi Osako, Yasuyuki Nishiyama et al. · Oncology · 2013 · 13.2K citations · Full text

Comprehensive molecular portraits of human breast tumours

Nature · 2012 · 12.1K citations · Full text

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Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet α granules and differentially released

Joseph E. Italiano, Jennifer L. Richardson, Sunita Patel–Hett et al. · Blood · 2007 · 835 citations · Full text

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

An S. Tan, James W. Baty, Lan‐Feng Dong et al. · Cell Metabolism · 2015 · 738 citations · Full text

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