Publication | Open Access

Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects

Medicinal ChemistryBiochemistryMedicineNatural SciencesHypoxia-activated ProdrugPharmacological AgentRock InhibitorSystemic Side-effectsPharmacotherapyDrug DevelopmentPharmacologyDrug Discovery