NRAS Mutations May Be Involved in the Pathogenesis of Cutaneous Rosai Dorfman Disease: A Pilot Study

Abstract

We report the <i>NRAS</i> mutation is common in cutaneous RDD, and <i>NRAS</i> A146T was the most frequent mutation in this cohort. Mutations in the <i>NRAS</i> gene can activate the RAS/MAPK signaling and have been reported to be associated with various cancers. It indicates that <i>NRAS</i> mutation in MAPK/ERK pathway may involve the pathogenesis of cutaneous RDD.