Electroacupuncture Alleviates Inflammation of Dry Eye Diseases by Regulating the <i>α</i>7nAChR/NF‐<i>κ</i>B Signaling Pathway

Abstract

These results prove that EA can alleviate DEDs by stimulating the acupoints around the eyes. These beneficial effects are related to the upregulation of <i>α</i>7nAChR and the downregulation of NF-<i>κ</i>B in the LG. The protective effect of LG is mediated through the anti-inflammatory pathway mediated by <i>α</i>7nAChR. EA can reduce the NF-<i>κ</i>B P65 nuclear transcription and reduce inflammatory factors by regulating <i>α</i>7nAChR. This expression indicates that the <i>α</i>7nAChR/NF-<i>κ</i>B signaling pathway may serve as a potential therapeutic target for EA to treat DEDs.