1,8-cineole ameliorates ischaemic brain damage via TRPC6/CREB pathways in rats

Abstract

Our study provides in vivo evidence demonstrating that cineole pretreatment attenuates ischaemic stroke-induced brain damage, mainly through blocking calpain-induced TRPC6 degradation and activating CREB via MEK/CREB and CaMKIV/CREB signalling pathways.