An introgressed gene causes meiotic drive in <i>Neurospora sitophila</i>

Abstract

Significance In order to survive, most organisms must deal with parasites. Such parasites can be other organisms or, sometimes, selfish genes found within the host genome itself. While much is known about parasitic organisms, the interaction with their hosts, and their ability to spread within and between species, much less is known about selfish genes. We here identify a selfish “spore killer” gene in the fungus Neurospora sitophila . The gene appears to have evolved within the genus but has entered the species through hybridization and introgression. We also show that the host can counteract the gene through RNA interference. These results shed light on the diversity of selfish genes in terms of origin, evolution, and host interactions.