Role of the high-affinity reductive iron acquisition pathway of <i>Candida albicans</i> in prostaglandin E2 production, virulence, and interaction with <i>Pseudomonas aeruginosa</i>

Abstract

Iron uptake is vital for disease-causing microbes like Candida albicans. Using strains deficient in some iron-uptake genes, we show that iron-uptake genes, especially FET99 and FTH2, play a role in biofilm formation, prostaglandin production, and virulence in the nematode infection model.