High‐Frequency Oscillations in the Pallidum: A Pathophysiological Biomarker in Parkinson's Disease?

Abstract

Our findings provide evidence in support of the hypothesis that exaggerated, movement-modulated high-frequency oscillations in the GPi are pathophysiological features of PD. These findings suggest that the functional role(s) of high-frequency oscillations may differ between the STN and GPi and motivate additional investigations into their relationship to motor control in normal and diseased states.