Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalcones <i>via</i> palladium(<scp>ii</scp>)-catalyzed oxidative cyclization

Abstract

Divergent and versatile synthetic routes to flavones and flavanones <i>via</i> efficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2'-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives, <i>via</i> discriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.