Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury

Abstract

The activation of Adrb2 signaling in macrophages induces anti-inflammatory phenotypic alterations partially via the induction of <i>Tim3</i> expression, which blocks LPS-induced systemic inflammation and protects against renal IRI.