Distribution of mucosal PD-1 expressing T cells in patients with colitis of different etiologies

Abstract

There are relevant differences in distribution and frequencies of mucosal PD-1⁺ T-cell subsets in patients with UC, CD, InfC and ImC, supporting the hypothesis that these types of colitis are driven by different immunological pathways. The increased numbers of PD-1⁺ and PD-L1⁺ lymphocytes in the colonic mucosa of UC patients suggest that the PD-1/PD-L1 pathway might be more activated in UC than in CD.