Concepedia

A hybrid mechanistic-empirical model for in silico mammalian cell bioprocess simulation

Conor M. O’Brien, Qi Zhang, Pródromos Daoutidis, Wei‐Shou Hu

Metabolic Engineering · 2021 · 51 citations · 30 references

DOI

Concepts

References

30

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

A-S. Marsin, Luc Bertrand, Mark H. Rider et al. · Current Biology · 2000 · 824 citations · Full text

, , +12

Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)

Kay Barnes, Jean C. Ingram, Omar Porras et al. · Journal of Cell Science · 2002 · 285 citations · Full text

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Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

Francesca Zagari, Martin Jordan, Matthieu Stettler et al. · New Biotechnology · 2012 · 198 citations

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Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

Hương Giang Lê, Santosh Kabbur, Luciano Pollastrini et al. · Journal of Biotechnology · 2012 · 178 citations

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On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

Bhanu Chandra Mulukutla, Michael J. Gramer, Wei‐Shou Hu · Metabolic Engineering · 2012 · 167 citations

, , +14