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The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/ Akt/Smad pathway
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2015
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InflammationTissue EngineeringPi3k/ Akt/smad PathwayHepatologyBiliary TractMedicineLiver PhysiologyPathologyCell DeathHepatotoxicityLiver DiseaseHepatology FibrosisPharmacologyCell BiologyCell SignalingDrug-induced Liver InjuryOxidative StressAnti-fibrotic Effects
目的:(−；)-Epigallocatechin-3-gallate (EGCG ) 是在有强壮的抗氧化剂活动和各种各样的治疗学的效果的绿茶的最丰富的多酚之一。在这研究，我们在胆汁调查了 EGCG 和内在的机制的 anti-fibrotic 效果绑扎管(BDL ) 老鼠和肝纤维变性在 vitro 当模特儿。