Synthesis and their evaluation for their antimicrobial activity of diphenyl piperazine-based sulfanilamides

Abstract

The novel diphenyl piperazine-based sulfanilamides were conveniently and efficiently synthesized via multi-step reactions starting from commercially available acetanilide and (4-chlorophenyl)(phenyl)methanone. The synthesized title compounds and their intermediates were characterized by ¹H NMR, ¹³C NMR, IR and MS spectra as well as elemental analyses and screened <italic>in vitro</italic> for their antibacterial and antifungal activities. The antimicrobial activity showed that the target compounds 14 and 16 exhibited better inhibitory potency than sulfanilamide against all tested bacterial strains.