Comparison of Simoa^TM and Ella^TM to assess serum neurofilament‐light chain in multiple sclerosis

Abstract

We compared Simoa^TM and Ella^TM immunoassays to assess serum neurofilament-light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The Ella^TM instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to Ella^TM results. As for Simoa^TM , serum neurofilament-light chain levels measured by Ella^TM were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice.