American Journal of Physiology-Renal Physiology · 2021 · 29 citations · 49 references
Life SciencesBiochemistryMolecular BiologyInnate ImmunityMedical MicrobiologyRenal PathophysiologyAntimicrobial PeptidesRenal ImmunopathologyUrinary Tract Infection PreventionUrinary Tract InfectionsAntibacterial PeptidesAntimicrobial Peptide ActivityAntimicrobial Peptide Gene RegulationAntimicrobial Peptide ProductionAntimicrobial Peptide ResponseRibonuclease ChemistryUrinary Tract Infection PathogenesisUrinary Tract Injury
Ribonuclease 4 (RNase 4) is a newly identified host defense peptide in the human kidney and bladder. RNase 4 kills uropathogenic Escherichia coli (UPEC) and multidrug-resistant UPEC. RNase 4 prevents invasive UPEC infection and suppressed RNase 4 expression may be a risk factor for more severe or recurrent urinary tract infection.
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Antimicrobial peptides of multicellular organisms
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