Association of polymorphisms in <i>ZFHX1B</i>, <i>KCNQ5</i> and <i>GJD2</i> with myopia progression and polygenic risk prediction in children

Abstract

In this study, multi-tiered evidence suggested SNPs in <i>ZFHX1B</i>, <i>KCNQ5</i> and <i>GJD2</i> as risk factors for myopia progression in children. Additional attention and appropriate interventions should be given for myopic children with high-risk PRS as defined by <i>GJD2</i> rs524952, <i>KCNQ5</i> rs7744813 and <i>ZFHX1B</i> rs13382811.