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Betaine inhibits Toll-like receptor 4 expression in rats with ethanol-induced liver injury
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2010
Year
ImmunologyOxidative StressInflammationMolecular PharmacologyEthanol-induced Liver InjuryAnimal ModelsHepatotoxicityEthanol FeedingHealth SciencesLiver PhysiologyAlcohol AbuseAlcohol-related Liver DiseasePharmacologyToll-like Receptor 4Drug-induced Liver InjuryAlcohol DependenceSubstance AbuseAnti-inflammatoryHepatologyPhysiologyLiver DiseaseMedicine
AIM:To test whether ethanol feeding could induce Toll-like receptor 4(TLR4)responses,assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models of alcoholic liver injury.METHODS:Forty-eight female Sprague-Dawley rats were randomly divided into four groups as control,model,low and high dose betaine groups.Except control group,all rats were fed with high fat-containing diet plus ethanol and fish oil gavages for 8 wk.Betaine was administered intragastrically after exposure...