PubMed · 2021 · 27 citations · 0 references
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MedicineCancer BiologyOncologyMetastasisMolecular OncologySignal TransductionCancer Cell SignalingCancer ProgressionGastric CancerMalignant NeoplasmsOncogenic Signaling PathwaysSignal Transduction In CancerCancer Metastasis MechanismsCancer Signaling PathwaysLymph Node Metastasis PrognosisMetastatic SignalingPhosphatidylinositol 3-Kinase-akt PathwayPi3k-akt Signaling PathwayTumor Metastasis BiologyTumor Stage Prognosis
. Furthermore, we demonstrate that FSTL1 is involved in regulation of the AKT signaling through analyzing databases and experimental results. Mechanistic studies showed that FSTL1 promoted proliferation, migration and invasion in GC, at least partially, by activating AKT via regulating TLR4/CD14. In all, this study highlights the role of the FSTL1-TLR4/CD14-AKT axis, which provided novel insights into the mechanism of growth and metastasis in GC for the first time.