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Polymorphisms of GSTP1 is associated with differences of chemotherapy response and toxicity in breast cancer
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2011
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Breast OncologyToxicity.the 新陈代谢限制， CyclophosphamideGenetic EpidemiologyHuman PolymorphismPathologyImmune-related Gene PolymorphismToxicological MechanismDrug ResistanceMolecular PharmacologyOncologyPolymorphisms.the 在人口是多态的这研究的目的是检验效果基因 PolyToxicologyRadiation OncologyCancer ResearchHealth SciencesChemotherapy ResponseCancer GeneticsDrug DevelopmentPharmacologyExperimental ToxicologyBiomolecular EngineeringBreast CancerMedicine
背景尽管化疗是乳癌的最重要的治疗之一，它被重要 inter-individuval 变化在反应和 epirubicin ( EPI )的 toxicity.The 新陈代谢限制， cyclophosphamide ( CTX )被细胞色素 P450s ( CYP )主要调停，谷胱甘肽 S-transferases ( GST ) .It 是著名的这些酶的活动由于他们的基因 polymorphisms.The 在人口是多态的这研究的目的是检验效果基因 poly