Non-smoking: a feature of ulcerative colitis.

Abstract

We suggest that chlormethiazole may have caused dysphagia by a direct action on the central mechanisms concerned in swallowing.Most reports of the adverse effects of this drug concentrate on the problems of drug abuse and addiction,3 and dysphagia has not been reported as a side effect.There have been some reports of dyspepsia, nausea, and vomiting related to the acidity of the tablets.4This is unlikely to have been important in the present case, however, since no reflux was detected during overnight recording.Further studies are needed to investigate the prevalence and mechanism of oesophageal dysfunction in patients taking this drug.