A Two‐Photon H₂O₂‐Activated CO Photoreleaser

Abstract

Carbon monoxide (CO) is proposed as an active pharmaceutical agent with promising pharmaceutical prospects, as it has been involved in multifaceted modulation of diverse physiological and pathological processes. However, questions remain for therapeutic application of inhaled CO attributed to the inherent great affinity between CO and hemoglobin. Therefore, a robust platform with the function of CO transport and controllable release, depending on the local status of an organism, is of prominent significance for effectively avoiding the side effects of CO inhalation and optimizing the biological regulation function of CO. Utilizing the oxidative stress biomarker H₂ O₂ as a trigger and combining with photo-control, a two-photon H₂ O₂ -activated CO photoreleaser, FB, featuring highly sensitive and specific H₂ O₂ sensing and photocontrollable CO release, was developed and the vasodilation effect of CO against angiotensin II was demonstrated.