Clinical Infectious Diseases · 2021 · 40 citations · 11 references
Veterinary MedicineInfectious Disease ControlInfectious DiseasesImmunizationVaccinologyVirologyMrna Vaccine TechnologyVaccinationVaccine EffectivenessVaccine EfficacyViral InfectionsViral VaccinesCoronavirus Infection PreventionCoronavirus Respiratory InfectionCoronavirus VaccinesPeriodic Surveillance TestingSars-cov-2 InfectionSevere Acute Respiratory SyndromeVaccination Against Respiratory InfectionsVaccination Against Respiratory Pathogens
In nursing home residents with asymptomatic COVID-19 diagnosed through twice-weekly surveillance testing, single-dose BNT162b2 vaccination (Pfizer-BioNTech) was associated with -2.4 mean log10 lower nasopharyngeal viral load than detected in absence of vaccination (P = .004). Since viral load is linked to transmission, single-dose mRNA SARS-CoV-2 vaccination may help control outbreaks.
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