Bioconjugate Chemistry · 2021 · 17 citations · 46 references
PharmacyMedicinal ChemistryPharmacologyAntibody EngineeringCancer PharmacologyMolecular ImagingAntibody ConjugatesAntibody ConjugationAntibody-drug ConjugatesLigand BindingTargeted Imaging AgentsTargeting LigandsAntibody Targeting LigandsAntibody-based Imaging AgentsAntibody-based RadiotracersBifunctional ChelatorsConjugation Chemistry For AntibodiesMolecular Targeting LigandsPet RadiopharmaceuticalsReceptor-targeted Imaging Agents
Zr]Zr-dfo-dtm-trastuzumab possess high stability in biological milieu. Dibromomaleimide technology can be easily applied to enable stable, site-specific attachment of radiolabeled chelators, such as sar and dfo, to native interstrand disulfide regions of antibodies, enabling tracking of antibodies with PET imaging.
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