Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination

Abstract

Serum neutralizing antibodies rapidly appear after SARS-CoV-2 infection 1 and vaccination 2 and are maintained for several months. The emergence of SARS-CoV-2 variants has raised concerns about the breadth of neutralizingantibody responses. We compared the neutralizing-antibody response to 4 variants in infected and vaccinated individuals to determine how mutations within the spike protein are associated with virus neutralization.