Theranostics · 2021 · 52 citations · 0 references
Life SciencesBiochemistryEndocrinologyCellular MetabolismMetabolic RegulationMolecular Cell BiologyDiabetes MellitusGlucose HomeostasisGlycolysis RegulationInsulin ResistancePancreatic EndocrinologyPancreatic HormonesAdenovirus BiologyAdenovirus VectorsGlucose-dependent Insulin SecretionGlucose-stimulated Insulin SecretionGlycolytic Enzyme IsoformsGlycolytic Flux ControlImpaired Glucose TolerancePancreatic Islet Cells
SIRT2 ablation inhibits GSIS through blocking GKRP protein degradation and promoting ALDOA protein degradation, resulting in a decrease in glycolytic flux.