Natural Product Research · 2021 · 16 citations · 23 references
Two new pyrone derivatives, 2-(12<i>S</i>-hydroxypropyl)-3-hydroxy-methyl-6-hydroxy-7-methoxychromone (<b>1</b>), and (±)-pyrenocine S (<b>5</b>), together with five known compounds xanthoradone A (<b>2</b>), (+)-3,3',7,7',8,8'-hexahydroxy-5,5'-dimethyl-bianthra-quinone (<b>3</b>), butyrolactone-I (<b>4</b>), pyrenocine A (<b>6</b>), and (±)-pyrenocine E (<b>7</b>) were obtained from the mangrove endophytic fungus <i>Aspergillus</i> sydowii #2B. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis and comparison data with of literatures. Compounds <b>2</b>, <b>3</b>, <b>4</b>, <b>5</b>, <b>6</b> and <b>7</b> showed cytotoxicities against prostate cancer VCaP cells with IC<sub>50</sub> values of 4.19 ± 1.02, 33.36 ± 1.42, 1.92 ± 0.82, 20.06 ± 2.01, 7.92 ± 0.86, and 10.13 ± 0.88 μM respectively, while compound <b>1</b> showed no cytotoxic activity. Compounds <b>1</b>, <b>3</b>, <b>6</b>, and <b>7</b> exhibited weak inhibition effects against the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW 246.7 cells with IC<sub>50</sub> values of 40.15, 28.69, 25.25 and 43.08 μM respectively.
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