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Exploring the Reactivity of Propargylic Ester: Acyloxy and Acyl Migratory Rearrangement Relay Enabled by Formal Double Isocyanide Insertion
18
Citations
61
References
2021
Year
EngineeringMolecular BiologyOrganic ChemistryChemistryHeterocycle ChemistryStereoselective SynthesisTransition Metal‐free ConditionsBiochemistryDiversity-oriented SynthesisPropargylic EsterPropargylic PivalateAsymmetric CatalysisAcyl MigrationEnantioselective SynthesisBiomolecular EngineeringHeterocyclicAlkene MetathesisNatural SciencesSynthetic Chemistry
Abstract A rearrangement of propargylic pivalate with isocyanide under transition metal‐free conditions is disclosed. Intermolecular 1,3‐acyloxy and acyl migration enables the rapid formation of a C( sp 2 )−C( sp 3 ) bond from a C−O bond and the synthesis of polysubstituted 5‐iminopyrrolones. magnified image
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