Advanced Synthesis & Catalysis · 2021 · 18 citations · 61 references
Natural SciencesChemistryOrganic ChemistryHeterocycle SynthesisHeterocyclic ChemistryMigratory InsertionOrganic SynthesisRetrosynthetic AnalysisAcyl MigrationMigratory Insertion Mechanism
Abstract A rearrangement of propargylic pivalate with isocyanide under transition metal‐free conditions is disclosed. Intermolecular 1,3‐acyloxy and acyl migration enables the rapid formation of a C( sp 2 )−C( sp 3 ) bond from a C−O bond and the synthesis of polysubstituted 5‐iminopyrrolones. magnified image
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Total Synthesis of Ecteinascidin 743
Atsushi Endo, Arata Yanagisawa, Masanao Abe et al. · Journal of the American Chemical Society · 2002 · 288 citations