Concepedia

The ABC-Type Efflux Pump MacAB Is Involved in Protection of Serratia marcescens against Aminoglycoside Antibiotics, Polymyxins, and Oxidative Stress

Tatiana V. Shirshikova, Cecilia G. Sierra-Bakhshi, Leisan Kh. Kamaletdinova, Lilia E. Matrosova, Nailya Khabipova, Vladimir G. Evtugyn, Irina V. Khilyas, Iuliia V. Danilova, Lydia M. Bogomolnaya

mSphere · 2021 · 46 citations · 67 references

DOIFull text

Open access

Concepts

Abstract

The opportunistic pathogen Serratia marcescens can cause urinary tract infections, respiratory infections, meningitis, and sepsis in immunocompromised individuals. These infections are challenging to treat due to the intrinsic resistance of S. marcescens to an extensive array of antibiotics.

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