1e:T496,Chemodynamic therapy (CDT) utilizes iron-initiated Fenton chemistry to destroy tumor cells by converting endogenous H₂ O₂ into the highly toxic hydroxyl radical (^. OH). There is a paucity of Fenton-like metal-based CDT agents. Intracellular glutathione (GSH) with ^. OH scavenging ability greatly reduces CDT efficacy. A self-reinforcing CDT nanoagent based on MnO₂ is reported that has both Fenton-like Mn²⁺ delivery and GSH depletion properties. In the presence of HCO₃^- , which is abundant in the physiological medium, Mn²⁺ exerts Fenton-like activity to generate ^. OH from H₂ O₂ . Upon uptake of MnO₂ -coated mesoporous silica nanoparticles (MS@MnO₂ NPs) by cancer cells, the MnO₂ shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn²⁺ , resulting in GSH depletion-enhanced CDT. This, together with the GSH-activated MRI contrast effect and dissociation of MnO₂ , allows MS@MnO₂ NPs to achieve MRI-monitored chemo-chemodynamic combination therapy.1f:T47b,As a mussel-inspired material, polydopamine (PDA), possesses many properties, such as a simple preparation process, good biocompatibility, strong adhesive property, easy functionalization, outstanding photothermal conversion efficiency, and strong quenching effect. PDA has attracted increasingly considerable attention because it provides a simple and versatile approach to functionalize material surfaces for obtaining a variety of multifunctional nanomaterials. In this review, recent significant research developments of PDA including its synthesis and polymerization mechanism, physicochemical properties, different nano/microstructures, and diverse applications are summarized and discussed. For the sections of its applications in surface modification and biomedicine, we mainly highlight the achievements in the past few years (2016-2019). The remaining challenges and future perspectives of PDA-based nanoplatforms are discussed rationally at the end. This timely and overall review should be desirable for a wide range of scientists and facilitate further development of surface coating methods and the production of PDA-based materials.20:T629,

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