Advanced Genetics · 2021 · 34 citations · 86 references
Life SciencesBioengineeringBiotechnologyGenetic EngineeringGenome EditingSynthetic BiologyBiosafety RegulationMicrobial Synthetic BiologyBarriersBiotechnology Risk AssessmentGovernance Of BiotechnologyInteragency PartnershipsPotential BarriersPublic Engagement In BiotechnologyPublic Understanding Of BiotechnologySynthetic Biology Governance
Synthetic biology research and technology translation has attracted growing interest from governments and private investors in Asia, where it is seen as a key driver of a sustainable bio‑based economy. This perspective reviews the latest developments in enabling technologies and their applications in bio‑manufacturing, medicine, food, and agriculture in Asia, while examining how technology, education, and regulation can mitigate potential biosecurity risks. The authors discuss the field’s enabling technologies and applications, identify barriers such as inadequate infrastructure and policy, and propose solutions including public‑private partnerships, stronger multilateral collaboration, and robust governance frameworks. Asia’s strengths—advances in genome editing, widespread bio‑foundries, abundant natural resources, and large markets—position stakeholders from academia, industry, and government to establish innovation and bio‑economy hubs across the region.
Abstract Synthetic biology research and technology translation has garnered increasing interest from the governments and private investors in Asia, where the technology has great potential in driving a sustainable bio‐based economy. This Perspective reviews the latest developments in the key enabling technologies of synthetic biology and its application in bio‐manufacturing, medicine, food and agriculture in Asia. Asia‐centric strengths in synthetic biology to grow the bio‐based economy, such as advances in genome editing and the presence of biofoundries combined with the availability of natural resources and vast markets, are also highlighted. The potential barriers to the sustainable development of the field, including inadequate infrastructure and policies, with suggestions to overcome these by building public‐private partnerships, more effective multi‐lateral collaborations and well‐developed governance framework, are presented. Finally, the roles of technology, education and regulation in mitigating potential biosecurity risks are examined. Through these discussions, stakeholders from different groups, including academia, industry and government, are expectantly better positioned to contribute towards the establishment of innovation and bio‐economy hubs in Asia.
86
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin, Ruiqiang Li, Jeroen Raes et al. · Nature · 2010 · 11.7K citations · Full text
Nucleic acid detection with CRISPR-Cas13a/C2c2
Jonathan S. Gootenberg, Omar O. Abudayyeh, Jeong Wook Lee et al. · Science · 2017 · 3.8K citations · Full text
A bacterium that degrades and assimilates poly(ethylene terephthalate)
Shosuke Yoshida, Kazumi Hiraga, Toshihiko Takehana et al. · Science · 2016 · 3.2K citations
CRISPR–Cas12-based detection of SARS-CoV-2
James P. Broughton, Xianding Deng, Guixia Yu et al. · Nature Biotechnology · 2020 · 2.8K citations · Full text
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
Jonathan S. Gootenberg, Omar O. Abudayyeh, Max J. Kellner et al. · Science · 2018 · 2.6K citations · Full text