Concepedia

Association between T follicular helper cells and T peripheral helper cells with B-cell biomarkers and disease activity in primary Sjögren syndrome

Anastasia Dupré, Juliette Pascaud, Élodie Rivière, Audrey Paoletti, Bineta Ly, Michaël Mingueneau, Xavier Mariette, Gaëtane Nocturne

RMD Open · 2021 · 29 citations · 15 references

DOIFull text

Open access

Concepts

Abstract

T peripheral helper (Tph) cells are a newly described subtype of T lymphocytes. They are elevated in the blood of patients with pSS and correlate with circulating plasmablasts.

References

15

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Deepak A. Rao, Michael F. Gurish, Jennifer L. Marshall et al. · Nature · 2017 · 1.1K citations · Full text

, , +16

PD-1hiCXCR5– T peripheral helper cells promote B cell responses in lupus via MAF and IL-21

Alexandra V. Bocharnikov, Joshua Keegan, Vanessa Sue Wacleche et al. · JCI Insight · 2019 · 317 citations · Full text

, , +17

Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma

Elena Pontarini, William Murray‐Brown, Cristina Croia et al. · Annals of the Rheumatic Diseases · 2020 · 183 citations · Full text

, , +17

Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome

Krisztina Szabó, Gábor Papp, Sándor Baráth et al. · Clinical Immunology · 2013 · 179 citations · Full text

, , +16

Attenuation of Follicular Helper T Cell–Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome

Gwenny M. Verstappen, Petra M. Meiners, Odilia B. J. Corneth et al. · Arthritis & Rheumatology · 2017 · 174 citations · Full text

, , +17