Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis

Abstract

We found that inulin had many similar beneficial effects in the gut and brain for both <i>E3</i>FAD and <i>E4</i>FAD mice, which may be protective for brain functions and reduce risk for neurodegeneration. . <i>E3</i>FAD and <i>E4</i>FAD mice also had distinct responses in several metabolic pathways, suggesting an APOE-dependent nutrigenetic effects in modulating systemic metabolism and neuroprotection.