Concepedia

KRASG12C/TP53 co-mutations identify long-term responders to first line palliative treatment with pembrolizumab monotherapy in PD-L1 high (≥50%) lung adenocarcinoma

Nikolaj Frost, Jens Kollmeier, Claudia Vollbrecht, Christian Grah, Burkhard Matthes, Dennis Pultermann, Maximilian von Laffert, H Lüders, Elisabeth Olive, Matthias Raspe,

Translational Lung Cancer Research · 2021 · 55 citations · 36 references

DOIFull text

Open access

Abstract

A comprehensive assessment of KRAS subtypes and TP53 mutations allows a highly relevant prognostic differentiation of patients with metastatic, PD-L1 high LuAD treated upfront with pembrolizumab.

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