Cytocompatibility, membrane disruption, and siRNA delivery using environmentally responsive cationic nanogels

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Otmane Boussif, Frank Lezoualc’h, Maria Antonietta Zanta et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Pharmacy, Biotechnology, Pharmaceutics +17

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Zachary R. Chalmers, Caitlin Connelly, David Fabrizio et al. · Genome Medicine · 2017 · 3.7K citations · Full text

Medicine, Cancer Biology, Oncology +17

Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes

N.D. Sonawane, Francis C. Szoka, A.S. Verkman · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +14

<em>Ex Vivo</em> Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs

Brian C. Evans, Christopher E. Nelson, Shann S. Yu et al. · Journal of Visualized Experiments · 2013 · 356 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +13

Broad-Spectrum Antimicrobial Peptides by Rational Combinatorial Design and High-Throughput Screening: The Importance of Interfacial Activity

Ramesh Rathinakumar, William F. Walkenhorst, William C. Wimley · Journal of the American Chemical Society · 2009 · 317 citations · Full text

Natural Sciences, Biochemistry, Microbiology +17